Description

About Tectonic Therapeutic:

Tectonic is a clinical stage biotechnology company focused on the discovery and development of therapeutic proteins and antibodies that modulate the activity of G-protein coupled receptors (GPCRs). Tectonic’s founders are at the forefront of scientific research in biochemistry and molecular pharmacology. Their extensive track record of achievements includes major contributions to the development of multiple approved therapies for the treatment of cancer, autoimmune diseases, and beyond. 

Job Summary

We are looking for a motivated, independent, and flexible research scientist to join our Protein Biochemistry group. In this laboratory-based role, you will apply your expertise to generate material to support discovery of novel biologics. You will play a key role in a multi-disciplinary drug discovery team and will provide robust technical support for multiple projects. A successful candidate will be a highly organized and process-minded scientist that executes efficient experiments with the ability to analyze, interpret, and present results to project teams.

Your main responsibilities will include but are not limited to: .

     Maintenance and transient transfection of large-scale suspension cultures of HEK293 cells to support antigen production

     Purification of proteins including analysis of protein quality by SDS-PAGE and Western blot 

     Perform routine cloning (e.g. Gibson assembly) and generation/maintenance of DNA stocks for transfections

     Work in a focused, methodical, and independent fashion within a team to meet project goals and objectives 

     Analyze and present results in an effective manner at team meetings

     Maintain primary laboratory equipment and a detailed electronic notebook

Requirements

What you bring to the role: 

     BA/BS/MS in chemistry, biochemistry, or related field, with 2+ pharmaceutical/biotech experience preferred. Title will be commensurate with experience. 

     Direct experience with tissue culture of suspension mammalian cell lines (HEK293, CHO) using sterile technique

     Training in general protein biochemistry methods (e.g. IMAC, SEC) and experience running SDS-PAGE and Western blots to analyze protein purity and yield

     Hands-on experience with molecular biology techniques (cloning, DNA isolation, and large-scale DNA preparation)

     Exceptional organizational skills and proven ability to manage multiple tasks efficiently in a fast-paced work environment

     Comfortable working in an agile and team-oriented matrix environment, communicating with colleagues across functions and disciplines

     Ability to maintain a thorough, well-organized experimental lab notebook (ELN) to support reproducibility and team collaboration 

     Preferred:

     Familiarity with GPCRs or antibody discovery

     Experience with chromatography (Akta and HPLC systems)

     Understanding of ELN best practices (ideally Benchling)

Interested applicants may write to jobs@tectonictx.com with attached cover letter and CV in PDF format. We are an equal opportunity employer. All applicants will be considered for employment solely on the basis of on business needs, job requirements and individual qualifications, without attention to age, race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.