Description

About Generate:Biomedicines

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with over 275 employees.

The Role: 

We are seeking a creative and ambitious Computational Biologist with a strong background in next generation sequencing (NGS) to join our team. In this role, the successful candidate will collaborate closely with colleagues in the wet and dry labs to design novel NGS-based assays characterizing the phenotypes of large protein variants libraries. These assays will play a foundational role in Generate’s platform, allowing us to rapidly iterate through design, build, test, and learn cycles while maximizing our learning rate. This role is based in our Somerville, MA office with flexibility for hybrid work. 

Here's how you will contribute:

• Collaborate with wet lab scientists to design novel NGS-based assays that characterize the phenotypes of large, multiplexed, protein variant libraries.
• Identify key assay variables to characterize, measuring their impact on an assay’s ability to discern a phenotype of interest.
• Work with colleagues in data science and machine learning teams to establish protocols to feed analyzed assay data to our machine learning models. Join cross-functional teams of Generate scientists to identify and characterize molecules for use in pharmaceutical programs.
• Collaborate with other members of the Computational Biology team to codify best-practices for novel NGS-based assays and productionize these assays for regular program use.
• Detail the capabilities and potential applications of developed assays to various audiences, including scientists from different disciplines and management.
• Evaluate project needs and suggest the appropriate assay to meet research objectives. 

Requirements

The Ideal Candidate will have:

• Master's or PhD in Computational Biology, Computer Science, or a related field with 6+ years of experience.
• Demonstrated expertise in the design of novel NGS-based assays.
• Strong experience in developing novel statistical analysis methods to extract signal from noise in complex, multiplexed NGS assays.
• Broad familiarity with state-of-the-art bioinformatics tools including aligners, assemblers, variant callers, etc.
• Experience in developing and debugging NGS pipelines using popular workflow frameworks.
• Strong software engineering skills using Python and popular scientific packages like Numpy and Scipy.
• Established record of working collaboratively across wet lab and dry lab teams to develop and deliver novel assays. 

Who Will Love This Job:

• A creative problem solver passionate about leveraging computational biology to transform therapeutic development.
• A detail-oriented individual with a strong statistical background and a passion for NGS data analysis.
• A collaborative scientist who thrives working across teams and specialties to push science forward. 
  
  

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

COVID Safety:

Generate:Biomedicines enforces a mandatory vaccination policy for COVID-19. All employees must be fully vaccinated and have received a booster.  The purpose of this policy is to safeguard the health of our employees, their families, and the community at large from infectious disease that may be reduced by vaccinations.  The Company will make exceptions to this policy if required by applicable law and will consider requests for an exemption from this policy due to a medical reason, or because of a sincerely held religious belief, or any other exemptions that may be recognized by applicable.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.